Expression of Tumor Necrosis Factor α Converting Enzyme in Endocrine Cancers
نویسندگان
چکیده
منابع مشابه
Expression of tumor necrosis factor-_ converting enzyme (TACE) in endocrine cancers
(2008) Expression of tumor necrosis factor [alpha] converting enzyme in endocrine cancers. ABSTRACT Tumor necrosis factor-_ converting enzyme (TACE) mediates shedding of human epidermalgrowth factor receptor-4 (HER4). Recent data suggests that released HER4 intracellulardomain (4ICD) induces apoptosis in breast cancer.TACE expression, as measured by immunohistochemistry, was observed in 183/383...
متن کاملExpression of tumor necrosis factor-alpha--converting enzyme and tumor necrosis factor-alpha in human myocarditis.
OBJECTIVES We determined whether tumor necrosis factor-alpha-converting enzyme (TACE) is expressed with tumor necrosis factor-alpha (TNF-alpha) in myocarditis. BACKGROUND Tumor necrosis factor-alpha-converting enzyme, which has recently been identified as belonging to the family of metalloproteinase disintegrin proteins, is responsible for the conversion of TNF-alpha precursor to its mature f...
متن کاملTumor necrosis factor alpha-converting enzyme mediates MUC5AC mucin expression in cultured human airway epithelial cells.
Ectodomain shedding of epidermal growth factor receptor (EGFR) ligands [e.g., transforming growth factor type alpha (TGF-alpha)] and EGFR phosphorylation are implicated in mucin production in airway epithelial cells. Tumor necrosis factor alpha-converting enzyme (TACE) is reported to cleave precursor of TGF-alpha, with release of soluble mature TGF-alpha in various epithelial tissues. We hypoth...
متن کاملP2X7 Receptor Induces Tumor Necrosis Factor-α Converting Enzyme Activation and Release to Boost TNF-α Production
Tumor necrosis factor (TNF)-α is a major pro-inflammatory cytokine produced in response to toll-like receptor stimulation. TNF-α release is controlled by the activity of TNF-α converting enzyme (TACE) that cut membrane-bound TNF-α to shed its ectodomain as a soluble cytokine. The purinergic receptor P2X ligand-gated ion channel 7 (P2X7) is activated in response to elevated concentrations of ext...
متن کاملIncreased expression of tumor necrosis factor-alpha converting enzyme and tumor necrosis factor-alpha in peripheral blood mononuclear cells in patients with advanced congestive heart failure.
BACKGROUND Tumor necrosis factor-alpha converting enzyme (TACE) has recently been identified as a metalloproteinase-disintegrin, which converts pro-tumor necrosis factor-alpha (TNF-alpha) to the mature form, and is an important mediator in the pathogenesis of CHF. AIMS In order to establish the importance of TACE in the regulation of TNF-alpha synthesis in peripheral blood mononuclear cells (...
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ژورنال
عنوان ژورنال: American Journal of Clinical Pathology
سال: 2008
ISSN: 0002-9173,1943-7722
DOI: 10.1309/n6yb6ydvf58ycnhn